Timothy Lane

Timothy Lane

Professor

Office phone number6638-2736 #1252

Interests

  • Science of Consciousness
  • Science of Self
  • Philosophy of Consciousness
  • Unresponsive Wakefulness Syndrome

The focus of my research concerns the nature of self, consciousness, and the relationship between these. I am concerned with conceptual, clinical, and empirical/experimental aspects. For a recent statement of my views see,

https://www.sciencedirect.com/science/article/pii/S1053810019303770?via%3Dihub

For a recent statement of how I regard alternative views on self and consciousness see,

https://www.tandfonline.com/doi/abs/10.1080/02643294.2020.1738364?needAccess=true

In philosophical discussions I have developed my views with reference to the Immunity-to-error Principle, e.g.,

https://www.jstor.org/stable/23039007?seq=1

And with reference to the Higher-Order Theory of Consciousness, e.g.,

https://mitpress.universitypressscholarship.com/view/10.7551/mitpress/9780262029346.001.0001/upso-9780262029346-chapter-005

I have also applied my ideas in experimental, neuroimaging contexts, e.g.,

 

https://www.tandfonline.com/doi/abs/10.1080/17470919.2015.1072582?journalCode=psns20

A conceptual version of this can be found here,

https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(16)00051-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1364661316000516%3Fshowall%3Dtrue

And I have applied these ideas in the context of clinical trials targeting pathologies such as Major Depressive Disorder, e.g.,

https://link.springer.com/article/10.1007/s11682-020-00364-w

As well as other neuroimaging investigations of Major Depressive Disorder,

https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14858

Likewise the investigation of pathologies like schizophrenia,

https://www.sciencedirect.com/science/article/abs/pii/S0920996420300256?via%3Dihub

I have also applied these ideas to the investigation of sleep, e.g.,

https://academic.oup.com/sleep/article/41/6/zsy056/4953260

And illusions, e.g.,

https://cognitiveresearchjournal.springeropen.com/articles/10.1186/s41235-016-0041-4

In addition, I have written about the nature of rationality,

https://www.sciencedirect.com/science/article/pii/B9780128046005000015

And the status of contemporary psychiatry,

https://ndpr.nd.edu/news/philosophy-and-psychiatry-problems-intersections-and-new-perspectives/

My principal research focus now is a clinical trial investigating the effects of zolpidem on patients who suffer from Unresponsive Wakefulness Syndrome (“vegetative state”). This project includes fMRI, FDG-PET scanning, as well as the administration of zolpidem. The ongoing clinical trial is, in part, an extension of previous work by our team,

https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.22883

Finally, I am in the beginning stages of developing a clinical trial that concerns General Anesthesia.

For more information on my research, pedagogy, or other duties, see these URLs:

http://consciousbrain.tmu.edu.tw/index.php?lang=3

https://nrc.tmu.edu.tw/en/members/

https://www.journals.elsevier.com/consciousness-and-cognition/editorial-board

https://www.researchgate.net/profile/Timothy_Lane4

https://scholar.google.com.tw/citations?user=tWFAqhEAAAAJ&hl=en

https://loop.frontiersin.org/people/346735/overview

https://www.ea.sinica.edu.tw/people/Timothy-Joseph-Lane.aspx?lang=e

https://orcid.org/0000-0002-8608-4270

In my schoolboy days, my mentors included Carl G. Hempel, Julian Jaynes, Herbert Simon, and Tony O’Dea. If anything true and non-trivial is discovered through my investigations, it is due to the intellectual influence of these scholar-scientists. All failings, however, reflect the failings of my rational imagination. By creating GIMBC and the Brain & Consciousness Research Centre (BCRC), I have sought to rejuvenate the wisdom of my mentors. GIMBC and BCRC were established, in part, to commemorate Hempel, Jaynes, Simon, and O’Dea.

 

List of recent publications:

2021 (February) Occipital gamma—aminobutyric acid and glutamate-glutamine

     alterations in major depressive disorder: An MRS study and meta-analysis.

     Psychiatry Research: Neuroimaging (Corresponding author)

     http://doi.org/10.1016/j.pscychresns.2020.111238

2020 (December) Reactivity of intrinsic activity temporal structure to a behavioural state change is correlated with depressive symptoms. European Journal of Neuroscience 52, 12, 4840-4850. (Corresponding author) DOI: 10.1111/ejn.14858

2020 (October) The minimal self hypothesis. Consciousness & Cognition.

     https://doi.org/10.1016/j.concog.2020.103029 (Single author)

2020 (July) Spontaneous thought-related network connectivity predicts sertraline effect on major depressive disorder. (1st author, equal contribution) Brain imaging and behavior. DOI: 10.1007/s11682-020-00364-w

2020 (July) Somebody is home. Cognitive Neuropsychology 37, 3-4, 193-196. 

    (Single author). DOI: 10.1080/02643294.2020.1738364

2020 (April) Intrinsic brain activity of subcortical-cortical sensorimotor system and psychomotor alterations in schizophrenia and bipolar disorder. Schizophrenia Research 218, 157-165. (Corresponding Author)

2020 Abnormal functional relationship of sensorimotor network with neurotransmitter-related nuclei via subcortical-cortical loops in manic and depressive phases of bipolar disorder. Schizophrenia Bulletin 46, 1, 163-174.  (Co-authored with Martino, Magioncalda, Conio, et al.)

2019 (November 22) Temporal preparation, impulsivity and short-term memory in

depression. (Co-authored with Hsu, Tzu-Yu, Lee, H-C, & Marcus Missal)

Frontiers in Behavioral Neuroscience.

2019 (August 2) Indication of Dynamic Neurovascular Coupling from Inconsistency Between EEG and fMRI Indices Across Sleep–Wake States. Sleep and Biological Rhythms. DOI:10.1007/s41105-019-00232-1 (Corresponding author)

2019 Instability of brain connectivity during nonrapid eye movement sleep reflects altered properties of information integration. Human Brain Mapping 40, 11, 3139-3410. DOI: 10.1002/hbm.24590 (Co-authored with Kung, Wu, et al.)

2018 (July) Strong Circadian Rhythms in the Choroid Plexus: Implications for

    Sleep-Independent Brain Metabolite Clearance. Journal of experimental neuroscience 12,1-4. (Co-authored with Myung, Wu, and Simmoneaux)

2018 (June) The neurophysiological basis of the discrepancy between objective and subjective sleep during sleep onset period: an EEG-fMRI study. Sleep 41, 6, zsy056, https://doi.org/10.1093/sleep/zsy056 (Corresponding author)

2018 (May) Vascular-metabolic and GABAergic inhibitory correlates of neural variability modulation. A combined fMRI and PET study. Neuroscience 379, 142-151. (Corresponding author)

2018 (March) Measuring Consciousness. Scientific American (Taiwan Edition) 193, 38-42. (Co-authored with P. Tseng, C. Wu, T. Hsu, J. Myung, N. Duncan)

2018 (February 15) Abnormal resting state connectivity in a substantia nigra-related striato-thalamo cortical network in a large sample of first-episode drug naïve patients with schizophrenia. Schizophrenia Bulletin 44(2):419-431. doi: 10.1093/schbul/sbx067. (Co-authored with Matino, Magioncalda, et al.)

2018 (January 13) Too fast or too slow? Time and neuronal variability in bipolar disorder—A combined theoretical and empirical investigation. (Co-authored with Northoff, Magioncalda, et al.) Schizophrenia Bulletin 44(1):54-64. doi: https://doi.org/10.1093/schbul/sbx050

2017 Rationality: Constraints and Contexts. Academic Press. (Co-edited with T. W. Hung.)

2017 Rationality and its contexts. In Hung, T. W. and Lane, T. Eds. Rationality: Constraints and Contexts. London: Academic Press.  pp. 3-13. (Single author)

2017 Is depressive rumination rational? In Hung, T. W. and Lane, T. Eds. Rationality: Constraints and Contexts.London: Academic Press. (First and corresponding author) pp. 119-143.

2017 (December 12) Switching to the rubber hand. Frontiers in Psychology—Cognitive Science. doi: 10.3389/fpsyg.2017.02172. (Equal contribution and corresponding author)   

2017 (October) Cerebral blood flow autoregulation is impaired in schizophrenia: A pilot study.  Schizophrenia Research 188:63-67. doi: 10.1016/j.schres.2017.01.015.  (Co-authored with Ku, et al.)

2017 (April 2) Philosophy and Psychiatry: Problems, intersections, and new perspectives.  Notre Dame Philosophical Reviews 16(4). https://ndpr.nd.edu/news/philosophy-and-psychiatry-problems-intersections-and-new-perspectives/ (Single author)

2017 Timing disownership experiences in the rubber hand illusion. Cognitive Research: Principles and Implications 2(1) 1-14. (First and corresponding author) DOI: 10.1186/s41235-016-0041-4

2017 (January 5) Attention and memory-driven effects in action studies.  Behavioral and Brain Sciences, pp. 48-49. doi:10.1017/S0140525X15000965, e229 (Corresponding author)

2016 (July) The trajectory of self. Cell: Trends in cognitive sciences. 20, 7, 481-482. (First and corresponding author).

2016 Spontaneous activity in default-mode network predicts ascription of self-relatedness to stimuli. Social Cognitive Affective Neuroscience 11, 4, 693-702. (Co-authored with P. Qin, G. Northoff, et al.)

2016 Resting state glutamate predicts pre-stimulus alpha increase during  

    self-relatedness—A combined EEG-MRS study on rest-self overlap. Social

Neuroscience 11, 3, 249-263 (Corresponding author)

2015 Self, belonging, and conscious experience: A critique of subjectivity theories of consciousness.  In R. Gennaro, Ed. Disturbed Consciousness: New Essays on Psychopathology and Theories of Consciousness.  Cambridge, MA: MIT Press. pp. 103-140.   (Single author)

2015 GABAA Receptor Deficits Predict Recovery in Patients With Disorders of

Consciousness: A Preliminary Multimodal [11C] Flumazenil PET and fMRI

Study. Human Brain Mapping 36, 10, 3867-3877 (Co-authored with P. Qin, G.

Northoff, et al.)

2014 When actions feel alien: An explanatory model.  In Hung, T. W. Ed. Communicative Action.  Springer Science+Business Media. pp. 53-74.  (Single author)

2012 Timing the rubber hand illusion: Owning the rubber hand involves substitution, not addition. Perception (Supplement), 41, 212.   (Co-authored with Su-Ling Yeh and An-Yi Chang.  

2012 Toward an Explanatory Framework for Mental Ownership. Phenomenology and the Cognitive Sciences 11(2): 251-286. (Single author)

2011 Self-Consciousness and Immunity. The Journal of Philosophy 108, 2: 78-99. (First and corresponding author)

2010 The Threshold of Wakefulness, the Experience of Control, and Theory Development.  Consciousness and Cognition 19: 1095-1096. (Co-authored with C. M. Yang)

2010 What Subjective Experiences Determine the Perception of Falling Asleep During the Sleep Onset Period? Consciousness and Cognition 19: 1084-1092.  (Co-authored with C. M. Yang et al.)

2010 The Ethics of False Belief.  EurAmerica Vol. 40, 3: 591-633. (Single author)

2010 Issues at the Intersection of Ethics, Evolution, and Neuroscience.  EurAmerica Vol. 40, 3: 519-527.  (Single author)

2010 Mental Ownership and Higher-Order Thought Analysis (July) 70, 3: 496-501.  (First and corresponding author)

2009 Higher-Order Thought and Pathological Selves: The Case of Somatoparaphrenia Analysis (October) 69: 661-668.  (Corresponding author and equal contribution)

2008 Higher-Order Thought and the Problem of Radical Confabulation The Southern Journal of Philosophy XLVI (1): 69-98. (First and corresponding author)