22 Sep2020

Depression is associated with disconnection of neurotransmitter-related nuclei in multiple sclerosis

Depression is associated with disconnection of neurotransmitter-related nuclei in multiple sclerosis


Matteo Martino, Paola Magioncalda, Mohamed Mounir El Mendili, Amgad Droby, Swetha Paduri, Simona Schiavi, Maria Petracca, Matilde Inglese

Depression is frequently associated with multiple sclerosis. In this work, we investigated and characterized specific functional brain alterations, along with their relationship with white matter microstructure changes, in patients affected by multiple sclerosis with depressive symptomatology, by using a combined resting-state functional MRI and diffusion MRI approach. We found that depressive symptomatology in multiple sclerosis is specifically associated to a functional disconnection of neurotransmitter-related nuclei, which in turn may be traced to a distinct spatial pattern of white matter alterations mainly involving the limbic network. These results contribute to elucidate the pathophysiology of affective symptomatology and its relationship with multiple sclerosis.

Published in Multiple Sclerosis Journal

Here is the link: https://pubmed.ncbi.nlm.nih.gov/32907463