Biochemical correlates of the temporal structure of neural activity

Understanding the biochemical underpinnings of the activity properties that we observe in human imaging studies is important for a complete understanding of the brain. Also important is gaining an understanding of the role of temporal complexity in brain function and how this is produced and maintained. This is because this structuring of activity appears to be of central importance to how the brain works, providing the background against which external stimuli can be processed and responded to. The neurotransmitters glutamate and GABA play a fundamental role across the whole brain, respectively mediating excitation and inhibition. Given this ubiquitous role, these transmitter systems will likely be of particular importance in answering these questions about activity complexity.

 

The aim of this project is to use multi-modal neuroimaging techniques to link the temporal properties of brain activity with inhibition and excitation. It uses a combination of resting-state fMRI and EEG scanning to access different metrics of complexity across the full frequency spectrum. We will then relate these functional properties to biochemical ones obtained using magnetic resonance spectroscopy.