Intrinsic brain activity and psychopathology in bipolar disorder

Bipolar disorder shows opposite alterations in the psychopathological dimensions, such as psychomotricity, affectivity, and thought, during the manic and depressive phases. These opposite psychopathological alterations may be related to distinct changes in the functional architecture of intrinsic brain activity, especially in the balancing between various large-scale networks. In turn, such network dysbalancing may be traced to changes in subcortical-cortical loops and neurotransmitter signaling.

This project aims to investigate the specific relationships between the core psychopathological alterations in mania and depression, altered network balancing, abnormal coupling of subcortical-cortical loops, and functional disconnection of neurotransmitter-related brainstem nuclei, by using resting state fMRI, EEG, and behavioral measurements in bipolar patients during manic and depressive phases.

The results from this work could help to build a working model of the relationship between brain functioning and psychopathology, prompting for a better understanding of the pathophysiology of bipolar disorder.

 

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Martino M*, Magioncalda P*, Conio B, Capobianco L, Russo D, Adavastro G, Tumati S, Tan Z, Lee HC, Lane T, Amore M, Inglese M, Northoff G. Abnormal functional relationship of sensorimotor network with neurotransmitter-related nuclei via subcortical-cortical loops in manic and depressive phases of bipolar disorder. Schizophr Bull. 2020 Jan. 46(1):163-174.

 

Conio B*, Martino M*, Magioncalda P*, Escelsior A, Inglese M, Amore M, Northoff G. Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders. Mol Psychiatry. 2020 Jan. 25(1):82-93.