Topic: Characterisation and Roles of Deep-Layer Cortical Neurons

Speaker: Dr. Sheena Tiong (University Malaya)

Time: 2023/08/22 (Tuesday) 15:00-17:00

Location: 504 Meeting room, Research and Teaching Building, SH Campus, Taipei Medical University


Cortical lamination is characteristic of the mammalian neocortex. The earliest born neurons form the deepest layer, of which only a minor proportion of its constituent neurons remain as the brain matures. These remnant neurons are heterogeneous in terms of cell morphology and gene expression. More interestingly, these deep-layer neurons extend their axons to specific cortical and subcortical sites, which substantially contribute to functional cortical circuitry development and organisation. However, factors that determine deep-layer neuron axon projection patterns and targets are largely elusive. Thus, it is important to carefully characterise these deep-layer cortical neurons in order to better understand their roles underlying circuitry orchestration within and beyond the cortex.