Speaker: Jung Lung Hsu MD, PhD
Topic: Neuroimaging in degenerative dementia
Date: 2019.12.13 (Fri.) 15:00 pm-17:00 pm
Location: 12F Conference room, Daan Campus, Taipei Medical University
Dementia is a clinical syndrome which composes of cognitive changes, behavior problem and daily activity changes. Many of different etiologies could produce the dementia syndrome. In them, about 60-70% of patients with dementia are neurodegenerative processes and the diagnosis of these patients with dementia need neuropathology evidence. Recently advanced of neuroimaging techniques provide us an opportunity to discriminate different degenerative dementia syndrome before patients receive autopsy.
Magnetic resonance imaging (MRI) remains at the core of differential diagnosis, with specific patterns of cortical and subcortical changes having diagnostic significance. Recent developments in molecular PET imaging techniques have opened the door for not only antemortem but early, even preclinical, diagnosis of underlying pathology. This is vital, as treatment trials are underway for pharmacological agents with specific molecular targets, and numerous failed trials suggest that earlier treatment is needed. In this presentation, I will provide the progression of neuroimaging in diagnosis of degenerative dementia. The pathophysiological process related to the dementia study by neuroimaging will be also provided.